Effects of inhaled bronchodilators and corticosteroids on exercise induced arterial hypoxaemia in trained male athletes
| Autor: | B M Lynn, Donald C. McKenzie, Alastair N.H. Hodges, Michael S. Koehle |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.drug_class Physical Therapy Sports Therapy and Rehabilitation Placebo Oxygen Consumption Double-Blind Method Heart Rate Bronchodilator Heart rate Administration Inhalation medicine Humans Orthopedics and Sports Medicine Albuterol Bronchitis Hypoxia Asthma Fluticasone Cross-Over Studies business.industry General Medicine respiratory system medicine.disease Crossover study respiratory tract diseases Bronchodilator Agents Androstadienes Anesthesia Breathing Salbutamol Exercise Test Drug Therapy Combination Original Article business medicine.drug circulatory and respiratory physiology Sports |
| Zdroj: | British journal of sports medicine. 39(12) |
| ISSN: | 1473-0480 |
| Popis: | Objectives:To determine the effect of prophylactic treatment with an inhaled bronchodilator and anti-inflammatory on arterial saturation (Sao2) in trained non-asthmatic male athletes with exercise induced arterial hypoxaemia (EIAH).Methods:Nine male athletes (mean (SD) age 26.3 (6.7) years, height 182.6 (7.9) cm, weight 79.3 (10.5) kg, Vo2max62.3 (6.3) ml/kg/min, Sao2min92.5 (1.1)%) with no history of asthma were tested in two experimental conditions. A combination of a therapeutic dose of salbutamol and fluticasone or an inert placebo was administered in a randomised crossover design for seven days before maximal cycling exercise. Oxygen consumption (Vo2), ventilation (Ve), heart rate (HR), power output, and Sao2were monitored during the exercise tests.Results:There were no significant differences between the drug (D) and placebo (P) conditions for minimal Sao2(D = 93.6 (1.4), P = 93.0 (1.1)%; p = 0.93) Vo2max(D = 61.5 (7.2), P = 61.9 (6.3) ml/kg/min; p = 0.91), peak power (D = 444.4 (48.3), P = 449.4 (43.9) W; p = 0.90), peak Ve(D = 147.8 (19.1), P = 149.2 (15.5) litres/min; p = 0.82), or peak heart rate (D = 182.3 (10.0), P = 180.8 (5.5) beats/min; p = 0.76).Conclusions:A therapeutic dose of salbutamol and fluticasone did not attenuate EIAH during maximal cycling in a group of trained male non-asthmatic athletes. |
| Databáze: | OpenAIRE |
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