Topical phenytoin nanostructured lipid carriers: design and development
| Autor: | Abd El-Gawad, Thanaa Mohamed Borg, Amira Motawea |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Phenytoin
Administration Topical Chemistry Pharmaceutical Skin Absorption Antiepileptic drug Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Hydrogel Polyethylene Glycol Dimethacrylate 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Distribution (pharmacology) Solubility Pharmacology Drug Carriers Chromatography Chemistry Organic Chemistry 021001 nanoscience & nanotechnology Lipids Nanostructures Bioavailability Nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Drug Development and Industrial Pharmacy. 44:144-157 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639045.2017.1386204 |
| Popis: | Phenytoin (PHT) is an antiepileptic drug that was reported to exhibit high wound healing activity. Nevertheless, its limited solubility, bioavailability, and inefficient distribution during topical administration limit its use. Therefore, this study aims to develop, characterize nanostructured lipid carriers (NLCs), and evaluate their potential in topical delivery of PHT to improve the drug entrapment efficiency and sustained release. The NLCs were prepared by hot homogenization followed by ultra sonication method using 2 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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