Expression of S100A Alarmins in Cord Blood Monocytes Is Highly Associated With Chorioamnionitis and Fetal Inflammation in Preterm Infants
| Autor: | Veronika Golubinskaya, Henri Puttonen, Ing-Marie Fyhr, Halfdan Rydbeck, Ann Hellström, Bo Jacobsson, Holger Nilsson, Carina Mallard, Karin Sävman |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Male CD14 Immunology Inflammation Chorioamnionitis Monocytes S100A8 03 medical and health sciences 0302 clinical medicine Pregnancy Placenta medicine Immunology and Allergy Humans S100A9 Original Research fetal inflammation Fetus business.industry Monocyte alarmins S100 Proteins Infant Newborn preterm birth medicine.disease Fetal Blood chorioamnionitis 030104 developmental biology medicine.anatomical_structure Cord blood cord blood Premature Birth Female medicine.symptom business lcsh:RC581-607 Biomarkers Infant Premature 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | Background: Preterm infants exposed to chorioamnionitis and with a fetal inflammatory response are at risk for neonatal morbidity and adverse outcome. Alarmins S100A8, S100A9, and S100A12 are expressed by myeloid cells and have been associated with inflammatory activation and monocyte modulation. Aim: To study S100A alarmin expression in cord blood monocytes from term healthy and preterm infants and relate results to clinical findings, inflammatory biomarkers and alarmin protein levels, as well as pathways identified by differentially regulated monocyte genes. Methods: Cord blood CD14+ monocytes were isolated from healthy term (n = 10) and preterm infants ( |
| Databáze: | OpenAIRE |
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