Cancer Risk After Iodine-131 Therapy for Hyperthyroidism
| Autor: | L.-E. Holm, P. Hall, K. Wiklund, G. Lundell, G. Berg, G. Bjelkengren, E. Cederquist, U.-B. Ericsson, A. Hallquist, L.-G. Larsson, M. Lidberg, S. Lindberg, J. Tennvall, H. Wicklund, J. D. Boice |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Hyperthyroidism Gastroenterology Cohort Studies Iodine Radioisotopes Risk Factors Neoplasms Internal medicine medicine Humans Risk factor Lung cancer Stomach cancer Aged Sweden Leukemia business.industry Stomach Cancer Middle Aged medicine.disease Confidence interval Surgery Radiation therapy medicine.anatomical_structure Standardized mortality ratio Oncology Female business Follow-Up Studies |
| Zdroj: | JNCI Journal of the National Cancer Institute. 83:1072-1077 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/83.15.1072 |
| Popis: | Cancer incidence was studied in 10,552 patients (mean age, 57 years) who received 131I therapy (mean dose, 506 MBq) for hyperthyroidism between 1950 and 1975. Follow-up on these patients was continued for an average of 15 years. Record linkage with the Swedish Cancer Register for the period 1958-1985 identified 1543 cancers occurring 1 year or more after 131I treatment, and the standardized incidence ratio (SIR) was 1.06 (95% confidence interval = 1.01-1.11). Significantly increased SIRs were observed for cancers of the lung (SIR = 1.32; n = 105) and kidney (SIR = 1.39; n = 66). Among 10-year survivors, significantly elevated risks were seen for cancers of the stomach (SIR = 1.33; n = 58), kidney (SIR = 1.51; n = 37), and brain (SIR = 1.63; n = 30). Only the risk for stomach cancer, however, increased over time (P less than .05) and with increasing activity administered (P = not significant). The risk for malignant lymphoma was significantly below expectation (SIR = 0.53; n = 11). Overall cancer risk did not increase with administered 131I dose or with time since exposure. The absence of any increase in leukemia adds further support to the view that a radiation dose delivered gradually over time is less carcinogenic than the same total dose received over a short time. Only for stomach cancer was a possible radiogenic excess suggested. |
| Databáze: | OpenAIRE |
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