Transient Receptor Potential Canonical Type 3 Channels - Their Evolving Role in Hypertension and Its Related Complications
| Autor: | Peijian Wang, Daoyan Liu, Zhiming Zhu, Martin Tepel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Cardiovascular System Transient receptor potential channel TRPC3 Hypertension/complications Internal medicine Target organ damages medicine Humans TRPC Cation Channels/physiology Transient receptor potential canonical type 3 channel Blood Pressure/physiology Pharmacology business.industry Calcium signaling medicine.disease Blood pressure Hypertension complications Pathophysiology of hypertension TRPC Cation Channels Cardiac hypertrophy Hypertension Cardiology Cardiology and Cardiovascular Medicine business Target organ |
| Zdroj: | Wang, P, Liu, D, Tepel, M & Zhu, Z 2013, ' Transient Receptor Potential Canonical Type 3 Channels-Their Evolving Role in Hypertension and Its Related Complications ', Journal of Cardiovascular Pharmacology, vol. 61, no. 6, pp. 455-460 . https://doi.org/10.1097/FJC.0b013e31828748a1 |
| Popis: | Recent studies indicate that transient receptor potential canonical type 3 (TRPC3) channels contribute to the regulation of blood pressure and vascular and renal function. Several studies show that TRPC3 dysfunction is associated with hypertension, atherosclerosis, cardiac hypertrophy, and cerebrovascular events. In this review, we summarize the role of TRPC3 channels in the cardiovascular system, and we focus on their pathophysiogical role in hypertension and related target organ damages. We provide new insight into the involvement of TRPC3 channels in the development of hypertension and its related complications. |
| Databáze: | OpenAIRE |
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