Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling
Autor: | Tino Krell, David Martín-Mora, Jose A. Gavira, Miguel A. Matilla |
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Přispěvatelé: | European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
ved/biology.organism_classification_rank.species
Virulence Human pathogen Review Biology medicine.disease_cause Microbiology 03 medical and health sciences medicine Model organism Molecular Biology 030304 developmental biology 0303 health sciences 030306 microbiology Pseudomonas aeruginosa ved/biology Chemotaxis Signaling Cell biology Infectious Diseases Chemosensory pathways Second messenger system Signal transduction Function (biology) |
Zdroj: | Microbiol Mol Biol Rev Digital.CSIC. Repositorio Institucional del CSIC instname |
Popis: | Bacteria have evolved a variety of signal transduction mechanisms that generate different outputs in response to external stimuli. Chemosensory pathways are widespread in bacteria and are among the most complex signaling mechanisms, requiring the participation of at least six proteins. These pathways mediate flagellar chemotaxis, in addition to controlling alternative functions such as second messenger levels or twitching motility. The human pathogen Pseudomonas aeruginosa has four different chemosensory pathways that carry out different functions and are stimulated by signal binding to 26 chemoreceptors. Recent research employing a diverse range of experimental approaches has advanced enormously our knowledge on these four pathways, establishing P. aeruginosa as a primary model organism in this field. In the first part of this article, we review data on the function and physiological relevance of chemosensory pathways as well as their involvement in virulence, whereas the different transcriptional and posttranscriptional regulatory mechanisms that govern pathway function are summarized in the second part. The information presented will be of help to advance the understanding of pathway function in other organisms. This study was supported by FEDER funds and the Fondo Social Europeo through grants from the Spanish Ministry for Science and Innovation to M.A.M. (PID2019-103972GA-I00) and the Spanish Ministry of Economy and Competitiveness to J.A.G. (BIO2016-74875-P) and T.K. (BIO2016-76779-P). |
Databáze: | OpenAIRE |
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