Maternal overnutrition during critical developmental periods leads to different health adversities in the offspring: relevance of obesity, addiction and schizophrenia
| Autor: | Gitalee Sarker, Daria Peleg-Raibstein, Rahel Kastli, Kathrin Litwan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Offspring media_common.quotation_subject Physiology lcsh:Medicine Diet High-Fat Article Fetal Development 03 medical and health sciences Mice 0302 clinical medicine Overnutrition Latent inhibition Neurochemical Pregnancy medicine Animals Humans Obesity Amphetamine lcsh:Science media_common Multidisciplinary business.industry Addiction lcsh:R Maternal Nutritional Physiological Phenomena medicine.disease Behavior Addictive Disease Models Animal 030104 developmental biology Schizophrenia Prenatal Exposure Delayed Effects Diseases of the nervous system lcsh:Q Female Metabolic syndrome business 030217 neurology & neurosurgery medicine.drug Neuroscience |
| Zdroj: | Scientific Reports, 9 (1) Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.3929/ethz-b-000381766 |
| Popis: | Maternal overnutrition during sensitive periods of early development increases the risk for obesity and neuropsychiatric disorders later in life. However, it still remains unclear during which phases of early development the offspring is more vulnerable. Here, we investigate the effects of maternal high-fat diet (MHFD) at different stages of pre- or postnatal development and characterize the behavioral, neurochemical and metabolic phenotypes. We observe that MHFD exposure at pre-conception has no deleterious effects on the behavioral and metabolic state of the offspring. Late gestational HFD exposure leads to more prominent addictive-like behaviors with reduced striatal dopamine levels compared to early gestational HFD. Conversely, offspring exposed to MHFD during lactation display the metabolic syndrome and schizophrenia-like phenotype. The latter, is manifested by impaired sensory motor gating, and latent inhibition as well as enhanced sensitivity to amphetamine. These effects are accompanied by higher striatal dopamine levels. Together, our data suggest that MHFD exposure during specific stages of development leads to distinct neuropathological alterations that determine the severity and nature of poor health outcome in adulthood, which may provide insight in identifying effective strategies for early intervention. Scientific Reports, 9 (1) ISSN:2045-2322 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|