In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment
| Autor: | Angel Xie, Xingcai Zhang, You-Nian Liu, Liu Deng, Jong Seung Kim, Jiang Ouyang, Chan Feng, Zhongmin Tang, Xinbing Sui, Xiaoyuan Ji, Junqing Wang, Na Kong, Wei Tao, Yihai Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Chronic wound Male Angiogenesis Photothermal Therapy media_common.quotation_subject Analgesic Drug Evaluation Preclinical Neovascularization Physiologic Inflammation Lidocaine Hydrochloride Pharmacology Cell Line Diabetes Mellitus Experimental Diabetes mellitus Human Umbilical Vein Endothelial Cells Medicine Animals Humans Anesthetics Local media_common Cell Proliferation Mice Inbred BALB C Wound Healing Multidisciplinary business.industry Thrombin Endothelial Cells Fibrinogen Lidocaine Phosphorus medicine.disease Diabetic Foot Smart Materials Physical Sciences medicine.symptom business Wound healing Gels |
| Zdroj: | Proc Natl Acad Sci U S A |
| Popis: | The treatment of diabetic ulcer (DU) remains a major clinical challenge due to the complex wound-healing milieu that features chronic wounds, impaired angiogenesis, persistent pain, bacterial infection, and exacerbated inflammation. A strategy that effectively targets all these issues has proven elusive. Herein, we use a smart black phosphorus (BP)-based gel with the characteristics of rapid formation and near-infrared light (NIR) responsiveness to address these problems. The in situ sprayed BP-based gel could act as 1) a temporary, biomimetic "skin" to temporarily shield the tissue from the external environment and accelerate chronic wound healing by promoting the proliferation of endothelial cells, vascularization, and angiogenesis and 2) a drug "reservoir" to store therapeutic BP and pain-relieving lidocaine hydrochloride (Lid). Within several minutes of NIR laser irradiation, the BP-based gel generates local heat to accelerate microcirculatory blood flow, mediate the release of loaded Lid for "on-demand" pain relief, eliminate bacteria, and reduce inflammation. Therefore, our study not only introduces a concept of in situ sprayed, NIR-responsive pain relief gel targeting the challenging wound-healing milieu in diabetes but also provides a proof-of-concept application of BP-based materials in DU treatment. |
| Databáze: | OpenAIRE |
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