Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma
| Autor: | Viktor P. Kolosov, Marina V. Antonyuk, Oxana Yu. Kytikova, Tatyana A. Gvozdenko, Yulia K. Denisenko, Tatyana P. Novgorodtseva, Juliy M. Perelman |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
QH301-705.5 Peroxisome proliferator-activated receptor Inflammation Review Article Bioinformatics Pathogenesis 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Pharmacology (medical) Biology (General) Receptor Transcription factor Asthma chemistry.chemical_classification business.industry Peroxisome medicine.disease Endocannabinoid system 030104 developmental biology chemistry 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) medicine.symptom business |
| Zdroj: | PPAR Research PPAR Research, Vol 2020 (2020) |
| ISSN: | 1687-4765 1687-4757 |
| Popis: | The complexity of the pathogenetic mechanisms of the development of chronic inflammation in asthma determines its heterogeneity and insufficient treatment effectiveness. Nuclear transcription factors, which include peroxisome proliferator-activated receptors, that is, PPARs, play an important role in the regulation of initiation and resolution of the inflammatory process. The ability of PPARs to modulate not only lipid homeostasis but also the activity of the inflammatory response makes them an important pathogenetic target in asthma therapy. At present, special attention is focused on natural (polyunsaturated fatty acids (PUFAs), endocannabinoids, and eicosanoids) and synthetic (fibrates, thiazolidinediones) PPAR ligands and the study of signaling mechanisms involved in the implementation of their anti-inflammatory effects in asthma. This review summarizes current views on the structure and function of PPARs, as well as their participation in the pathogenesis of chronic inflammation in asthma. The potential use of PPAR ligands as therapeutic agents for treating asthma is under discussion. |
| Databáze: | OpenAIRE |
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