The opposite-direction modulation of CD4+CD25+ Tregs and T helper 1 cells in acute coronary syndromes
| Autor: | Wei Zhang, He-xiang Cheng, Shu-fang Han, Min Shen, Guo-liang Jia, Peng Liu, Hu Li, Cheng-xiang Li, Yan-hong Fan, Lun Bu, Kang Cheng |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Immunology Myocardial Infarction Coronary Disease chemical and pharmacologic phenomena Coronary Artery Disease Angina Pectoris Angina Coronary artery disease Interleukin 21 Th2 Cells Humans Immunology and Allergy Medicine Angina Unstable cardiovascular diseases IL-2 receptor Myocardial infarction Aged business.industry Unstable angina Interleukin-2 Receptor alpha Subunit FOXP3 Forkhead Transcription Factors hemic and immune systems T-Lymphocytes Helper-Inducer T lymphocyte Middle Aged Th1 Cells medicine.disease Gene Expression Regulation Acute Disease business |
| Zdroj: | Clinical Immunology. 124:90-97 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2007.03.546 |
| Popis: | Different subsets of T lymphocytes have different functions in atherosclerosis advancement. T helper 1 cells and T regulatory 1 cells have been demonstrated to play opposite roles in rupture of atherosclerotic lesion. However, the role of novel subset of T regulatory cells, known as CD4+CD25+Foxp3+ T cells, remains largely unknown in coronary artery disease (CAD). In this study, we investigated the peripheral CD4+CD25+Foxp3+ T cells of patients with CAD and controls. The patients submitted were divided into three groups: stable angina pectoris (SA) group, unstable angina pectoris (UA) group and acute myocardial infarction (AMI) group. We analyzed the frequencies of peripheral CD4+CD25+Foxp3+ T cells and T helper 1/T helper 2 cells, expression of Foxp3 in CD4+CD25+ T subsets and cytokines pattern in patients and controls. We found that the reduction of CD4+CD25+Foxp3+ T lymphocytes was consistent with the expansion of Th1 cells in patients with unstable CAD. The reversed development between CD4+CD25+ Tregs and Th1 cells might contribute to plaque destabilization. |
| Databáze: | OpenAIRE |
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