Search for a schizophrenia susceptibility locus on human chromosome 22

Autor:	Lynn E. DeLisi, Mihael H. Polymeropoulos, Lynn R. Goldin, Carl R. Merril, Gail Shields, Angela M. Smith, Mark Poulter, Jeffrey Rubenstein, Antonio Vita, John Holik, Elliot S. Gershon, Hilary Coon, William Byerley, Timothy J. Crow, R. Lofthouse, Nicholas Bass, Carla Morganti, Mark Hoff
Rok vydání:	1994
Předmět:	Genetics Male Genotype Chromosomes Human Pair 22 Chromosome Mapping Locus (genetics) Biology Penetrance Complete linkage Pedigree Gene mapping Genetic marker Schizophrenia Humans Female Genetic Predisposition to Disease Lod Score Gene Chromosome 22 Genetics (clinical)
Zdroj:	American journal of medical genetics. 54(2)
ISSN:	0148-7299
Popis:	We used 10 highly informative DNA polymorphic markers and genetic linkage analysis to examine whether a gene locus predisposing to schizophrenia is located on chromosome 22, in 105 families with schizophrenia and schizoaffective disorder. The LOD score method, including analysis for heterogeneity, provided no conclusive evidence of linkage under a dominant, recessive, or penetrance free model of inheritance. Affected sib-pair analysis was inconclusive. Affected pedigree member analysis gave only suggestive evidence for linkage. Multipoint APM analysis, using 4 adjacent loci including D22S281 and IL2RB, a region of interest from the APM analysis, gave non-significant results for the three different weighting functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47a585714c6a67df4ccff36fcc7b941 https://pubmed.ncbi.nlm.nih.gov/8074169 Zobrazit plný text záznamu Plný text