Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter
| Autor: | T W Hermiston, Mark F. Stinski, Cheryl L. Malone |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Gene Expression Regulation
Viral Human cytomegalovirus Genes Viral viruses DNA Mutational Analysis Restriction Mapping Immunology Cytomegalovirus Biology medicine.disease_cause Microbiology Immediate-Early Proteins Structure-Activity Relationship Viral Proteins Viral Envelope Proteins Virology Gene expression medicine RNA Messenger Cloning Molecular Promoter Regions Genetic Gene Viral Structural Proteins chemistry.chemical_classification Regulation of gene expression Mutation Membrane Glycoproteins RNA medicine.disease Molecular biology Amino acid chemistry Insect Science Trans-Activators RNA Viral Research Article |
| Zdroj: | Journal of Virology. 64:3532-3536 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.64.7.3532-3536.1990 |
| Popis: | The immediate-early two (IE2) gene products of human cytomegalovirus negatively regulate gene expression from the major immediate-early promoter in permissive human fibroblasts. A mutational analysis of the IE2 proteins indicated that the carboxyl-terminal region is required for negative regulation. The IE2 proteins that lack amino acid residues 365 to 519, or the carboxyl-terminal amino acids failed to negatively regulate. Most of the amino-terminal portion of the IE2 protein was not required for negative regulation. A possible explanation of the negative effect on downstream expression by the IE2 proteins is discussed. |
| Databáze: | OpenAIRE |
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