Left lateral segment pediatric liver transplantation: a 25 year experience at Mount Sinai
| Autor: | Marcelo Facciuto, Kishore Iyer, Parissa Tabrizian, Jaime Chu, Ronen Arnon, Sukru Emre, Matthew Holzner, Deniz Balci, Jang Moon, Yun Kyung Jung, Dylan Adamson, Sander Florman, Myron Schwartz |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry Liver Diseases medicine.medical_treatment Graft Survival Metabolic disorder Gastroenterology Vascular complication Liver transplantation medicine.disease Living donor Liver Transplantation Surgery Liver disease Hepatic artery thrombosis Treatment Outcome Living Donors medicine Humans Lateral segment Child business Fulminant liver failure Retrospective Studies |
| Zdroj: | HPB. 24:817-824 |
| ISSN: | 1365-182X |
| Popis: | BACKGROUND Outcomes of left lateral segment (LLS) grafts in pediatric recipients were compared between living (LD-LLS) and deceased donor (DD-LLS) grafts. METHODS 195 LLS grafts (99DD-LLS-96LD-LLS) were analyzed with a median follow-up of 9.1years. The primary endpoints were overall patient/graft survival. RESULTS LD-LLS grafts were younger (0.9vs.1.4years, p = 0.039), more likely to have a fulminant liver failure (17.9%vs.5.3%,p = 0.002), less likely to have a metabolic disorder (6.3%vs.25.5%,p = 0.002), and less likely to be undergoing retransplantation (5.3% vs.16.2%,p = 0.015). There was a trend toward decreased hepatic artery thrombosis in LD-LLS grafts (6.6% vs. 15.5%,p = 0.054). No differences in the overall biliary complications occurred. The LD-LLS group had prolonged survival compared to the DD-LLS group with 10-year survival rates of 81%, and 74% (p = 0.005), respectively. LD-LLS grafts had longer graft survival compared to DD-LLS grafts (10-year graft survival 85%vs.67%,p = 0.005). Recipient age >1year (HR 2.39,p = 0.026), aortic reconstruction (HR 2.12,p = 0.046) and vascular complication (HR 3.12,p |
| Databáze: | OpenAIRE |
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