Renal Prostaglandins: Possible Regulators of the Renal Actions of Pressor Hormones
| Autor: | Keith Crowshaw, Norberto A. Terragno, J. C. McGiff, Andrew J. Lonigro |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Kidney Renal Veins Norepinephrine Dogs medicine.artery Internal medicine Animals Bioassay Medicine Renal artery Multidisciplinary business.industry Angiotensin II Venous blood Perfusion medicine.anatomical_structure Endocrinology Regional Blood Flow Depression Chemical Prostaglandins Chromatography Thin Layer business Hormone |
| Zdroj: | Nature. 227:1255-1257 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/2271255b0 |
| Popis: | WE describe here the release from the kidney by angiotensin II and noradrenaline of substances which have the properties of prostaglandins. This observation may help to account for the antihypertensive function of the kidney first suggested by Fasciolo1, who demonstrated that removal of the kidney contralateral to an ischaemic kidney produced sustained hypertension in dogs. We have adapted the bioassay method of Vane2, the super-fused blood-bathed organ technique, for the detection of prostaglandins in renal venous blood in response to infusions of arigioteiisin II or noradrenaline into the renal artery. |
| Databáze: | OpenAIRE |
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