Aryl H-phosphonates. 19. New anti-HIV pronucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries
| Autor: | Joanna Romanowska, Justyna Gołębiewska, Michal Sobkowski, Krystian Kolodziej, Tomasz Jakubowski, Marta Rachwalak, Jerzy Boryski, Aleksandra Dabrowska, Adam Kraszewski, Jacek Stawinski |
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| Rok vydání: | 2019 |
| Předmět: |
Anti-HIV Agents
Pyridines Organophosphonates Aminopyridines 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Drug Discovery Phosphoric Acids 030304 developmental biology Pharmacology 0303 health sciences 010405 organic chemistry Anti hiv Dideoxynucleosides Aryl Organic Chemistry Biological activity Phosphoramidate General Medicine Amides Combinatorial chemistry 0104 chemical sciences chemistry Drug Design Zidovudine |
| Zdroj: | European Journal of Medicinal Chemistry. 164:47-58 |
| ISSN: | 0223-5234 |
| Popis: | We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pronucleotides. Depending on the pKa values of the aminopyridines and the hydroxypyridines used, alternative synthetic strategies based on H-phosphonate chemistry were developed for their preparation. Synthetic aspects of these transformations and the biological activity of the synthesized compounds are discussed. |
| Databáze: | OpenAIRE |
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