Methotrexate-induced Leukoencephalopathy without Typical Restricted Diffusion on Diffusion-weighted Imaging and the Utility of Magnetic Resonance Spectroscopy to Support the Diagnosis

Autor:	Ha Son Nguyen, Saman Shabani, Karl Janich, Christopher R. Chitambar, Hayley Doan, Andrew Mountoure, Michael Gelsomino, Ninh Doan, Mohit Patel
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Coma musculoskeletal diseases medicine.medical_specialty business.industry medicine.drug_class Case Report General Medicine medicine.disease Antimetabolite magnetic resonance spectroscopy methotrexate Leukoencephalopathy Restricted Diffusion medicine Paralysis Methotrexate Radiology medicine.symptom business Diffusion MRI medicine.drug
Zdroj:	Asian Journal of Neurosurgery
ISSN:	2248-9614 1793-5482
Popis:	Methotrexate (MTX) is a common antimetabolite agent that is widely used today in treating leukemia, lymphoma, and osteosarcoma. Its use has been associated with leukoencephalopathy causing seizures, paralysis, and even coma. To achieve the best possible outcome, it is important to be able to make a prompt diagnosis. Studies reported restricted diffusion on diffusion-weighted imaging (DWI) which is a reliable early sign of acute MTX-induced leukoencephalopathy. However, we report here the first case of MTX-induced leukoencephalopathy without typical restricted diffusion on DWI and the utility magnetic resonance spectroscopy to support this diagnosis in the difficult case such as the one being presented here.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47058c270b1aec883665ef87504d67d http://europepmc.org/articles/PMC6159078 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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