Evaluation of [O-methyl-11C]fluvoxamine as a tracer for serotonin re-uptake sites
| Autor: | M. Rigamonti, F. Fazio, Mario Matarrese, P Wollmer, D. Soloviev, R LaGaetana, P. Simonelli, M Galli, G Ortu, R. M. Moresco |
|---|---|
| Přispěvatelé: | Wollmer, P, Moresco, R, Simonelli, P, Matarrese, M, Rigamonti, M, Ortu, G, La Gaetana, R, Soloviev, D, Kienle, M, Fazio, F |
| Rok vydání: | 2000 |
| Předmět: |
Male
Serotonin Cancer Research medicine.medical_specialty Central nervous system Fluvoxamine Serotonergic Binding site Brain metabolism Internal medicine medicine Animals Brain radionuclide imaging Tissue Distribution Radiology Nuclear Medicine and imaging Serotonin Uptake Inhibitors Serotonin uptake inhibitors Biotransformation Chemistry Serotonin metabolism Brain Metabolism Rats Endocrinology medicine.anatomical_structure Receptors Serotonin Molecular Medicine Macaca nemestrina Radiopharmaceuticals Reuptake inhibitor Emission computed tomography Selective Serotonin Reuptake Inhibitors Tomography Emission-Computed medicine.drug |
| Zdroj: | Nuclear Medicine and Biology. 27:177-181 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/s0969-8051(99)00106-7 |
| Popis: | We evaluated [ 11 C]fluvoxamine as a tracer for the serotonin re-uptake site. Studies of the distribution of the tracer in rat and primate brain showed adequate uptake of [ 11 C]fluvoxamine, but failed to reveal regions with known high density of serotoninergic re-uptake sites. Pretreatment with unlabeled fluvoxamine did not substantially change the distribution. In rat brain tissue, nearly all radioactivity represented intact [ 11 C]fluvoxamine. [ 11 C]Fluvoxamine does not function as a tracer for serotonin re-uptake sites, owing to high nonspecific binding in the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect