Molecular Characterization of the Prototrophic Salmonella Mutants Defective for Intraepithelial Replication
| Autor: | Rebecca L. Guy, Akamol E. Suvarnapunya, Murry A. Stein, Daniel V. Zurawski |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Salmonella
MutS DNA Mismatch-Binding Protein Auxotrophy Molecular Sequence Data Immunology Mutant Virulence Biology medicine.disease_cause Microbiology Cell Line Mice Bacterial Proteins medicine Animals Amino Acid Sequence Adenosine Triphosphatases Genetics Mice Inbred BALB C Mutation Escherichia coli Proteins Membrane Proteins Epithelial Cells Molecular Pathogenesis Molecular biology Pathogenicity island DNA-Binding Proteins Infectious Diseases Parasitology Intracellular |
| Zdroj: | Infection and Immunity. 71:2247-2252 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Three Mu d J prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88: 11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and 17-21. |
| Databáze: | OpenAIRE |
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