The effects of human leukocyte antigen DRB1*13 and apolipoprotein E on age-related variability of synchronous neural interactions in healthy women
| Autor: | Stacy Dolan, Apostolos P. Georgopoulos, Brian E. Engdahl, Arthur C. Leuthold, Angeliki Georgopoulos, Lisa M. James |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Adult Research paper Genotype Healthy brain aging Human leukocyte antigen Disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Atrophy Apolipoproteins E Gene Frequency medicine Humans Allele skin and connective tissue diseases HLA-DRB1 Neuroinflammation Aged Aged 80 and over business.industry DRB1*13 Age Factors Magnetoencephalography General Medicine Middle Aged medicine.disease Neural network 030104 developmental biology Immunology Female Nerve Net business 030217 neurology & neurosurgery HLA-DRB1 Chains |
| Zdroj: | EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Background Age-related brain changes are well-documented and influenced by genetics. Extensive research links apolipoprotein E (apoE) to brain function, with the E4 allele serving as a risk factor for brain disease, including Alzheimer's disease, and the E2 allele conferring protection. Recent evidence also supports protective effects of another gene, human leukocyte antigen (HLA) DRB1*13, on brain disease and age-related brain atrophy in cognitively healthy adults. Here we investigated the effects of apoE and HLA DRB1*13 on brain function by examining changes in neural network properties with age in healthy adults. Methods One hundred seventy-eight cognitively healthy women (28–99 y old) underwent a magnetoencephalography scan and provided a blood sample for genetic analysis. Age-related changes in neural network variability in genetic subgroups of DRB1*13 × apoE genotype combinations were assessed using linear regression of network variability against age. Findings For individuals lacking a DRB1*13 allele and/or carrying an apoE4 allele, network variability increased significantly with age. In contrast, no such increase was observed in the presence of DRB1*13 and/or apoE2. Interpretation These findings extend previous research documenting the protective effect of DRB1*13 on brain structure to include protection against age-related changes in brain function, and demonstrate similar protective effects on neural network variability for either DRB1*13 or apoE2. These protective effects could be due to reduction or elimination of factors known to disrupt brain function, including neuroinflammation and amyloid beta protein. Funding U.S. Department of Veterans Affairs, and University of Minnesota. |
| Databáze: | OpenAIRE |
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