Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination

Autor:	Sung Ran Kim, Hyeon Jeong Kang, Hye Rin Jeong, Su Yeon Jang, Jae Eun Lee, Da Eun Kim, Hae Ry Lee, Min Hee Cho, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Joon Young Song
Rok vydání:	2022
Předmět:	Vaccines Synthetic COVID-19 Vaccines SARS-CoV-2 Case-Control Studies Health Personnel Vaccination COVID-19 Humans mRNA Vaccines General Medicine
Zdroj:	Journal of Korean Medical Science. 37
ISSN:	1598-6357 1011-8934
DOI:	10.3346/jkms.2022.37.e267
Popis:	The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46aa3c0d915445845f6846c08f33f75 https://doi.org/10.3346/jkms.2022.37.e267 Zobrazit plný text záznamu