Daily intake and serum concentration of menaquinone-4 (MK-4) in haemodialysis patients with chronic kidney disease
| Autor: | Dariusz Suchy, Jerzy Chudek, Katarzyna Wyskida, Rafał Ficek, Kornel Pośpiech, Bogusław Okopień, Agnieszka Żak-Gołąb, Magdalena Olszanecka-Glinianowicz, Krzysztof Łabuzek, Andrzej Wiecek |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Daily intake Clinical Biochemistry Reference range Recommended Dietary Allowances Diet Records Hemostatics Limit of Detection Reference Values Renal Dialysis Internal medicine medicine Humans Risk factor Renal Insufficiency Chronic Vascular Calcification Vascular calcification Chromatography High Pressure Liquid business.industry Case-control study Decreased Concentration Vitamin K 2 General Medicine Vitamin K 1 Middle Aged medicine.disease Dietary Fats Endocrinology Case-Control Studies Female Dietary Proteins business Energy Intake Kidney disease |
| Zdroj: | Clinical biochemistry. 48(18) |
| ISSN: | 1873-2933 |
| Popis: | Decreased concentration of menaquinone-4 (MK-4) seems to be an important risk factor of vascular calcification in haemodialysis (HD) patients. Optimal dietary intake, as well as serum MK-4 reference range, in HD has not been determined, yet. The aim of the present study was to assess daily vitamin K1 and MK-4 intakes and their relation to serum MK-4 concentration in HD patients.Daily vitamin K1 and MK-4, micro- and macronutrients and energy intakes were assessed using 3-day food diary completed by patients and serum MK-4 concentration was measured by HPLC [limit of quantification (LOQ): 0.055 ng/mL] in 85 HD patients (51 males) and 22 apparently healthy subjects.Daily MK-4 intake was significantly lower (by 29%) among HD, while K1 consumption was similar in both groups. Daily MK-4 intake was associated with fat and protein consumption in HD (r=0.43, p0.001 and r=0.33, p=0.004, respectively). In HD serum MK-4 concentration was more frequently below LOQ (in 41% HD and 5% controls, p0.001) and in those HD with quantifiable values was lower than in the controls (by 42%). The correlations between MK-4 concentrations and both MK-4 and K1 daily intakes were weaker in HD (r=0.38 and r=0.30 respectively) than in the control group (r=0.47 and r=0.45, respectively). In multiple regression analysis the variability of serum MK-4 concentrations in HD patients was explained by its daily intake.Decreased serum MK-4 concentration in HD patients is caused by lower dietary MK-4 intake, mainly due to diminished meat consumption, and in addition, probably reduced K1 conversion. |
| Databáze: | OpenAIRE |
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