Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells
| Autor: | Yebin Lu, Xiong Chen, Xiaohui Duan, Juanjuan Hu, Weijia Sun |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Oncogene business.industry Cell immune escape Cancer Articles Pharmacology Cell cycle medicine.disease_cause medicine.disease Molecular medicine pancreatic carcinoma cells nitric oxide signaling pathway glyceryl trinitrate medicine.anatomical_structure Oncology Apoptosis Immunology cardiovascular system medicine business Carcinogenesis circulatory and respiratory physiology Transdermal |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm 3 , the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 µg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompat- ibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|