Clinical utility of mean platelet volume and immature platelet fraction in acute coronary syndrome
| Autor: | Chih-Hung Chen, Hsien-Li Huang, Chia-Te Kung, Yi-Chen Li, Yu-Hung Lin, Wan-Ting Huang, Pei-Hsun Sung, Huey-Ling You |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Blood Platelets Male medicine.medical_specialty Acute coronary syndrome Mean platelet volume Myocardial Infarction Immature Platelet 03 medical and health sciences 0302 clinical medicine Immature platelet fraction Internal medicine Troponin I medicine Odds Ratio Humans Platelet Whole blood Aged business.industry General Medicine Emergency department Middle Aged medicine.disease humanities respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis Cardiology Female Original Article business Emergency Service Hospital Biomarkers Blood sampling |
| Zdroj: | Biomedical Journal |
| ISSN: | 2320-2890 |
| Popis: | Background Platelets play an important role in the pathogenesis of acute coronary syndrome (ACS). Patients with ACS have an increased mean platelet volume (MPV) and immature platelet fraction (IPF) resulting in elevation of thrombotic ability. In this study, we evaluated the diagnostic performance of MPV and IPF in identifying suspected ACS patients at emergency department. Moreover, we investigated the correlation between MPV or IPF with initial troponin I (TnI), one of the current ACS biomarkers. Methods This was a single-center study recruiting suspected ACS patients who had acute chest pain at the emergency department. Whole blood samples were obtained from all participants and MPV and IPF were measured by Sysmex XE-5000 hematology analyzer within 20 min of blood sampling. The diagnostic values of MPV and IPF in identifying ACS were analyzed retrospectively. Result In this study, 63 in 104 suspected ACS patients were diagnosed as ACS (65.3%). MPV and IPF were higher in ACS patients compared to non-ACS patients (MPV: 10.7 ± 0.80 fL vs 10.0 ± 0.64 fL, p |
| Databáze: | OpenAIRE |
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