Influenza-like illness in pregnant women during summertime: clinical, epidemiological and microbiological features
| Autor: | M. C. Prados, N. Martínez-Sánchez, Guillermo Ortiz Ruiz, Jose R. Arribas, M. Muñoz-Muñiz, M. Sánchez-Pastor, Alejandro Martín-Quirós, Alicia Rico-Nieto, B. San-José, María Pilar Romero-Gómez, José Ramón Paño-Pardo, Marta Mora-Rillo |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Oseltamivir medicine.disease_cause Article Virus chemistry.chemical_compound Medical microbiology Pregnancy Nasopharynx Internal medicine Epidemiology Prevalence medicine Humans Pregnancy Complications Infectious Retrospective Studies H1N1 Virus Influenza-like illness Reverse Transcriptase Polymerase Chain Reaction business.industry Clinical course virus diseases General Medicine Respiratory Virus Influenza respiratory tract diseases Infectious Diseases chemistry Virus Diseases Viruses Pregnant Woman Immunology Respiratory virus Female Rhinovirus business |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-011-1248-4 |
| Popis: | It is not known whether influenza-like illnesses (ILI) in pregnant women caused by influenza virus, specifically, those caused by the 2009 Influenza A H1N1 virus (nH1N1), can be clinically distinguished from those caused by other agents. From 1st July 2009 until 20th September 2009, an observational study including all pregnant women presenting at Hospital Universitario La Paz with an ILI was carried out. A specific reverse-transcriptase polymerase chain reaction (RT-PCR) for nH1N1 in nasopharyngeal swabs was prospectively carried out in all patients. Retrospectively, samples were analysed for multiple respiratory virus panel (RT-PCR microarray). Clinical, demographical and other microbiological variables were evaluated as well. A total of 45 pregnant women with ILI were admitted. Of these, 14 (31.1%) women had nH1N1 infection and 11 with a non-influenza ILI (35.48%) were positive for other viruses (five rhinovirus, four parainfluenza virus, one bocavirus and one adenovirus). In 20 patients, no aetiologic agent was identified. The clinical course of nH1N1 was mild, without deaths or severe complications. No significant differences were found when comparing the clinical presentation and course of patients with and without nH1N1 infection. Six women with nH1N1 infection received oseltamivir. Influenza and non-influenza ILI were clinically indistinguishable among pregnant women. Many ILI in pregnant women remain undiagnosed, despite undergoing an RT-PCR microarray for several respiratory viruses. |
| Databáze: | OpenAIRE |
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