Investigation of the mechanism of propranolol-induced bronchoconstriction
| Autor: | Ursula M. Ney, Jennifer Maclagan |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Time Factors
Guinea Pigs Propranolol Pulmonary compliance Pharmacology Bronchospasm chemistry.chemical_compound Airway resistance Heart Rate medicine Pressure Animals Drug Interactions Practolol Lung Compliance Bronchial Spasm business.industry Airway Resistance respiratory system Atenolol respiratory tract diseases Rats chemistry Adrenal Medulla Bronchoconstriction medicine.symptom business Histamine medicine.drug Research Article |
| Zdroj: | British journal of pharmacology. 66(3) |
| ISSN: | 0007-1188 |
| Popis: | 1 Dose-related increases in airways resistance (Raw) and decreases in dynamic lung compliance (Cdyn) were recorded in guinea-pigs and rats following intravenous injection of propranolol and of the cardioselective beta-adrenoceptor blocking drugs, atenolol and practolol. 2 The bronchoconstriction reached a peak in 2 to 4 min and subsided within 15 min. Repeated injections caused identical responses in the airways. 3 The isomer (+)-propranolol, which has only weak beta-adrenoceptor blocking activity, produced identical responses when given alone or when given after a dose of the racemate, sufficient to cause measurable beta-adrenoceptor blockade in the lungs. 4 After the initial bronchospasm had subsided, the beta-adrenoceptor blocking drugs and the isomer, (+)-propranolol, produced potentiation of the bronchoconstrictor effects of 5-hydroxytryptamine and histamine. 5 Both the bronchospasm and the potentiation occurred in adrenal demedullated rats. 6 The results indicate that the bronchoconstrictor effects of these drugs are unrelated to beta-adrenoceptor blockade in the airway smooth muscle. |
| Databáze: | OpenAIRE |
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