C-S Coupling of DNA-Conjugated Aryl Iodides for DNA-Encoded Chemical Library Synthesis
| Autor: | Luo Huadong, Yue Ji, Wang Zhao, Jinqiao Wan, Jing Fan, Huiyong Ma, Guansai Liu, Jin Li, Dongliang Dai, Simin Shen, Min Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA damage
Biomedical Engineering Pharmaceutical Science Bioengineering 02 engineering and technology Conjugated system 01 natural sciences Chemical library chemistry.chemical_compound Sulfhydryl Compounds Pharmacology 010405 organic chemistry DNA-encoded chemical library Aryl Organic Chemistry Biological activity DNA Iodides 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Coupling (electronics) chemistry 0210 nano-technology Biotechnology |
| Zdroj: | Bioconjugate chemistry. 32(4) |
| ISSN: | 1520-4812 |
| Popis: | Thioethers have been widely found in biologically active compounds, including pharmaceuticals. In this report, a highly efficient approach to on-DNA construction of thioethers via Cu-promoted Ullmann cross-coupling between DNA-conjugated aryl iodides and thiols is developed. This methodology was demonstrated with medium to high yields, without obvious DNA damage. This reported reaction has strong potential for application in DNA-encoded chemical library synthesis. |
| Databáze: | OpenAIRE |
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