Large Deformation of a DNA‐Origami Nanoarm Induced by the Cumulative Actuation of Tension‐Adjustable Modules
| Autor: | Ibuki Kawamata, Yuki Suzuki, Satoshi Murata, Kohei Mizuno |
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| Rok vydání: | 2020 |
| Předmět: |
Flexibility (anatomy)
Materials science 010405 organic chemistry Tension (physics) Mechanical engineering General Chemistry General Medicine Deformation (meteorology) 010402 general chemistry 01 natural sciences Strength of materials Catalysis 0104 chemical sciences medicine.anatomical_structure medicine DNA origami A-DNA Relaxation (approximation) Contraction (operator theory) |
| Zdroj: | Angewandte Chemie. 132:6289-6293 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.201916233 |
| Popis: | Making use of the programmability and structural flexibility of the DNA molecule, a DNA-origami nanoarm capable of undergoing large deformation is constructed. This DNA-origami nanoarm comprised serially repeated tension-adjustable modules, the cumulative actuation of which resulted in a large deformation of the arm structure, which transformed from a linear shape into an arched shape. Combining atomic force microscopy and theoretical analyses based on the mechanics of materials, we demonstrate that the degree of deformation can be systematically controlled by merely replacing a set of strands that is required for the actuation of the module. Moreover, by employing a G-quadruplex-forming sequence for the actuation, we could achieve reversible ion-induced contraction and relaxation of the nanoarm. The adjustability and scalability of this design could enable the production of DNA nanodevices that exhibit large deformation in response to external stimuli. |
| Databáze: | OpenAIRE |
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