HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells
| Autor: | Michal Štros, Alireza Jian Bagherpoor, Aleš Hampl, Josef Jaroš, Martin Kučírek |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Telomerase Transcription Genetic Human Embryonic Stem Cells Cell Transfection Biochemistry HMGB2 03 medical and health sciences 0302 clinical medicine Transcription (biology) Genetics medicine HMGB2 Protein Humans HMGB1 Protein Progenitor cell Molecular Biology biology Stem Cells DNA replication Cell Differentiation Embryonic stem cell Cell biology Telomere 030104 developmental biology medicine.anatomical_structure biology.protein 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | The FASEB Journal. 33:14307-14324 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.201901465rrr |
| Popis: | High-mobility group box (HMGB)1 and HMGB2 proteins are the subject of intensive research because of their involvement in DNA replication, repair, transcription, differentiation, proliferation, cell signaling, inflammation, and tumor migration. Using inducible, stably transfected human embryonic stem cells (hESCs) capable of the short hairpin RNA-mediated knockdown (KD) of |
| Databáze: | OpenAIRE |
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