Role of Anti-Parietal Cell Antibody in Helicobacter pylori -associated Atrophic Gastritis: Evaluation in a Country of High Prevalence of Atrophic Gastritis
| Autor: | Masanori Ito, Tomoari Kamada, Shinji Tanaka, Masaharu Yoshihara, Atsunori Sasaki, Masaharu Sumii, Shunji Kaya, Kazuaki Chayama, Sun Jin Kim, Ken Haruma |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Gastritis Atrophic Male Adolescent Atrophic gastritis Spirillaceae Blotting Western Enzyme-Linked Immunosorbent Assay Helicobacter Infections Cohort Studies Atrophy Japan Risk Factors Prevalence Humans Medicine Prospective Studies Helicobacter Child Aged Probability Aged 80 and over Chi-Square Distribution Helicobacter pylori biology business.industry Gastroenterology Autoantibody Middle Aged biology.organism_classification medicine.disease Antibodies Anti-Idiotypic Gastric Mucosa Immunology biology.protein Female Antibody Gastritis medicine.symptom business |
| Zdroj: | Scandinavian Journal of Gastroenterology. 37:287-293 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Helicobacter pylori plays an important part in the progression of atrophic gastritis; however, markers for predicting the progression of atrophic gastritis remain unidentified. We investigated the relation between the degree of atrophic gastritis and the amount of anti-parietal cell antibodies (APCAs) present.In 219 Japanese patients, APCA was investigated by enzyme-linked immunosorbent assay (ELISA) and by Western blotting. The grade of corpus atrophy was estimated by histology and serum pepsinogen levels. Serum levels of pepsinogen were evaluated by radioimmunoassay.Helicobacter pylori infection did not affect the APCA levels determined by ELISA. Long-term administration of proton-pump inhibitors and H. pylori eradication did not influence the levels of APCAs. However, in H. pylori-positive patients, the levels of APCA determined by ELISA were statistically higher in patients with severe atrophy than in those with mild atrophy as determined histologically (0.67+/-0.48 versus 0.45+/-0.40; A492, mean+/-s, P=0.01) and serologically by pepsinogen levels (0.66+/-0.51 versus 0.44+/-0.40. P=0.002). The levels of pepsinogen I/II ratio were correlated with APCA levels only in the H. pylori-positive group. Western blotting showed that major antigen was identical with the beta-subunit of H+,K+-ATPase.APCA plays an important part in the progression of corpus atrophy after H. pylori infection. |
| Databáze: | OpenAIRE |
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