T cell response to N-formylated peptides in humans
Autor: | Luca Battistini, Maria Paola Perrone, Rosa Sorrentino, C. Montesperelli, Paolo Riccio, Daniela Tramonti, Franco Giubilei, Giovanni Ristori, A. Perna, Maria Teresa Fiorillo, Giovanna Borsellino, Alberto Chersi, Stefania Cannoni, Marco Salvetti, Carla Buttinelli |
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Rok vydání: | 2001 |
Předmět: |
Adult
CD4-Positive T-Lymphocytes Male T cell Immunology Receptors Antigen T-Cell Major histocompatibility complex Lymphocyte Activation Immunophenotyping Interferon-gamma Immune system Antigen T-Lymphocyte Subsets medicine Immunology and Allergy Cytotoxic T cell Humans Amino Acid Sequence Cells Cultured Genetics Antigen Presentation N-Formylmethionine biology Histocompatibility Antigens Class II T lymphocyte MHC restriction Middle Aged Clone Cells medicine.anatomical_structure biology.protein Female Interleukin-4 Peptides CD8 |
Zdroj: | European journal of immunology. 31(9) |
ISSN: | 0014-2980 |
Popis: | We present the first evidence of a T lymphocyte response to N-formylated peptides in humans. N-formylated peptide sequences from self (mitochondrial) and foreign (microbial) antigens were used to isolate antigen-specific T cell clones from healthy individuals, including a set of monozygotic twins. The observed response differed from that previously described in mouse (CD4(+) phenotype and MHC class II restriction in humans vs. CD8(+) phenotype and class I restriction in mice). These lymphocytes produce substantial amounts of IFN-gamma. They were isolated in only one of the monozygotic twins, which suggests that their expansion in the healthy immune repertoire is independent of the genetic background. Our result will help in assessing the relevance of N-formylated peptide-specific T cells in protection against infections within the human immune system. |
Databáze: | OpenAIRE |
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