The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients

Autor: Andrii Sydorchuk, Olexii Tkachuk, Petro Vasuliovuch Kyfiak, Andrii Popovich, Larysa Sydorchuk, Oksana Iftoda, Anna Kshanovska, Volodymyr Petrynych, O. Y. Khomko, Valentina Dzhuryak, R. P. Knut, R. I. Sydorchuk, Svitlana Levytska
Rok vydání: 2020
Předmět:
0301 basic medicine
Aldosterone synthase
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Renal function
Blood Pressure
030204 cardiovascular system & hematology
Polymorphism
Single Nucleotide
Diseases of the endocrine glands. Clinical endocrinology
Renin-Angiotensin System
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Diabetes mellitus
Internal medicine
medicine
Cytochrome P-450 CYP11B2
Humans
Diabetic Nephropathies
Genetic Predisposition to Disease
Aldosterone
Aged
Kidney
Creatinine
diabetes
biology
business.industry
cyp11b2 (rs1799998) gene
Middle Aged
RC648-665
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Blood pressure
chemistry
Diabetes Mellitus
Type 2
Case-Control Studies
Hypertension
biology.protein
Female
business
chronic kidney disease
Kidney disease
Glomerular Filtration Rate
Zdroj: Endocrine Regulations, Vol 54, Iss 3, Pp 217-226 (2020)
ISSN: 1336-0329
Popis: Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes. Methods. One-hundred hypertensive patients with target-organ damaging (2nd stage), moderate, high or very high cardiovascular risk were involved in the case-control study. Mean age was 59.87±8.02 years. Diabetes Mellitus type 2 (DM2) was in 28 persons. Chronic kidney disease (CKD) was diagnosed in 29 persons according to the National Kidney Foundation recommendations (2012) after glomerular filtration rate (GFR) decline CYP11B2 (-344C/T) was examined by polymerase chain reaction. Results. CKD evolution in hypertensive patients followed by higher systolic and diastolic blood pressure (SBP, DBP) values increased creatinine, cystatin-C, and aldosterone serum concentrations by 28.76%, 28.41% and 29.43% (рCYP11B2 (rs1799998) gene is associated with SBP and DBP increase (pТТ-genotype female carriers (pCYP11B2 gene polymorphic site with the increased aldosterone content (F=47.52; p Conclusions. Genetic variations involving CYP11B2 might influence the kidney function, hypertension course, and severity via aldosterone secretion upregulation.
Databáze: OpenAIRE
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