Progressive microstructural changes of the occipital cortex in Huntington's disease

Autor: Robert H. A. M. Reijntjes, Alexander Leemans, Raymund A.C. Roos, Simon J.A. van den Bogaard, Omar F. F. Odish
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Neurology
Pattern Recognition
Automated
Behavioral Neuroscience
0302 clinical medicine
Middle occipital gyrus
Image Processing
Computer-Assisted
Medicine
Longitudinal Studies
Neuroradiology
Language
Original Research
05 social sciences
Neuropsychology
Occipital cortex
Huntington's disease
Middle Aged
Psychiatry and Mental health
Huntington Disease
Diffusion tensor imaging
Radiology Nuclear Medicine and imaging
Cardiology
Disease Progression
Female
Occipital Lobe
Huntington’s disease
Adult
medicine.medical_specialty
Cognitive Neuroscience
Clinical Neurology
050105 experimental psychology
03 medical and health sciences
Cellular and Molecular Neuroscience
Internal medicine
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Inverse correlation
Longitudinal biomarker
Premanifest
business.industry
medicine.disease
Diffusion Magnetic Resonance Imaging
Nerve Degeneration
Stroop Test
Neurology (clinical)
business
030217 neurology & neurosurgery
Stroop effect
Diffusion MRI
Follow-Up Studies
Zdroj: Brain Imaging and Behavior, 12(6), 1786-1794
Brain Imaging and Behavior
Brain Imaging and Behavior, 12(6), 1786. Springer New York
ISSN: 1931-7557
Popis: In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington’s disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two year follow-up scans. The preHD group was stratified based on the predicted years to disease onset into a far (preHD-A) and near (preHD-B) to disease onset group. Clinical and behavioral measures were collected per assessment time point. An automated atlas-based DTI analysis approach was used to obtain the mean, axial and radial diffusivities of the occipital cortex. We found that the longitudinal rate of diffusivity change in the superior occipital gyrus (SOG), middle occipital gyrus (MOG), and inferior occipital gyrus (IOG) was significantly higher in early HD compared to both preHD and controls (all p’s ≤ 0.005), which can be interpreted as an increased rate of microstructural degeneration. Furthermore, the change rate in the diffusivity of the MOG could significantly discriminate between preHD-B compared to preHD-A and the other groups (all p’s ≤ 0.04). Finally, we found an inverse correlation between the Stroop Word Reading task and diffusivities in the SOG and MOG (all p’s ≤ 0.01). These findings suggest that measures obtained from the occipital cortex can serve as sensitive longitudinal biomarkers for disease progression in preHD-B and early HD. These could in turn be used to assess potential effects of proposed disease modifying therapies. Electronic supplementary material The online version of this article (10.1007/s11682-018-9849-5) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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