The pLysRS-Ap4A Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State
| Autor: | Lakshmi Bhargavi Paruchuru, Ehud Razin, Sharmila Govindaraj |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Proteases
QH301-705.5 pLysRS-Ap4A signaling Inflammation Review Biology Catalysis Inorganic Chemistry Pathogenesis chemistry.chemical_compound Immune system mast cell activation medicine Animals Humans Mast Cells Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Organic Chemistry Chemotaxis General Medicine Acquired immune system Immunity Innate Computer Science Applications Cell biology Chemistry allergic disease chemistry host defense pathological condition medicine.symptom Signal transduction Inflammation Mediators Histamine Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5620, p 5620 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The innate and adaptive immune systems play an essential role in host defense against pathogens. Various signal transduction pathways monitor and balance the immune system since an imbalance may promote pathological states such as allergy, inflammation, and cancer. Mast cells have a central role in the regulation of the innate/adaptive immune system and are involved in the pathogenesis of many inflammatory and allergic diseases by releasing inflammatory mediators such as histamines, proteases, chemotactic factors, and cytokines. Although various signaling pathways are associated with mast cell activation, our discovery and characterization of the pLysRS-Ap4A signaling pathway in these cells provided an additional important step towards a full understanding of the intracellular mechanisms involved in mast cell activation. In the present review, we will discuss in depth this signaling pathway’s contribution to host defense and the pathological state. |
| Databáze: | OpenAIRE |
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