Laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol
| Autor: | David S. Hodgson, James K. Roush, Nathaniel Kapaldo, Emily Klocke, Rose M. McMurphy, Kara Berke |
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| Rok vydání: | 2020 |
| Předmět: |
Male
040301 veterinary sciences Laryngoscopy Pregnanediones 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs 030202 anesthesiology medicine Animals Vocal cord paralysis Propofol Cross-Over Studies General Veterinary medicine.diagnostic_test Isoflurane business.industry Alfaxalone 04 agricultural and veterinary sciences medicine.disease Crossover study medicine.anatomical_structure Rima glottidis Laryngeal paralysis Anesthesia business medicine.drug |
| Zdroj: | Veterinary anaesthesia and analgesia. 48(4) |
| ISSN: | 1467-2995 |
| Popis: | To assess laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol.Randomized experimental crossover study.A group of 12 purpose-bred, male Beagle dogs.Dogs were randomly assigned to one of two treatments: alfaxalone-isoflurane (ALF-ISO) or propofol-isoflurane (PRO-ISO) and anesthetized for three video laryngoscopy examinations. The alternate treatment occurred after ≥ 14 days interval. Examinations were performed after induction of anesthesia (LS-A), after 20 minutes of breathing isoflurane via a facemask (LS-B) and after a further 20 minutes of isoflurane (LS-C). Parameters of objective laryngeal function included inspiratory rima glottidis surface area (RGSA-I), expiratory rima glottidis surface area (RGSA-E) and % RGSA increase, calculated from three consecutive respiratory cycles in the final 15 seconds of each video laryngoscopy examination. The % RGSA increase was calculated using [(RGSA-I - RGSA-E)/RGSA-E] × 100. Subjective laryngeal function was evaluated independently by two experienced surgeons blinded to treatment.The % RGSA increase within each treatment was greater for LS-B and LS-C than for LS-A (ALF-ISO: p = 0.03, PRO-ISO: p =0.001). There was no difference within each treatment from LS-B compared with LS-C. RGSA-I increased within each treatment from LS-A to both LS-B and LS-C (ALF-ISO: p = 0.002) and to LS-C (PRO-ISO: p = 0.006). Subjective laryngeal function scores improved from LS-A to LS-C.Laryngeal function improved from postinduction examination following either 20 or 40 minutes of anesthesia with isoflurane via facemask. This study demonstrates that isoflurane may have a lesser effect on arytenoid abduction activity compared with more commonly used intravenous induction anesthetics (alfaxalone and propofol). |
| Databáze: | OpenAIRE |
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