Antigen-specific NK cell memory in rhesus macaques
| Autor: | Jamie L. Schafer, Cordelia Manickam, R. Keith Reeves, Ulrich H. von Andrian, Valerie Varner, Haiying Li, Dan H. Barouch, Marcus Altfeld, Eryn Blass, Leila Eslamizar, Stephanie Jost, Hualin Li |
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| Rok vydání: | 2015 |
| Předmět: |
Immunology
Simian Acquired Immunodeficiency Syndrome Biology Article CD49b Interleukin 21 NK-92 Immunology and Allergy Animals Antigen-presenting cell AIDS Vaccines Lymphokine-activated killer cell Janus kinase 3 Dendritic Cells Virology Macaca mulatta 3. Good health Killer Cells Natural Liver Interleukin 12 Myeloid-derived Suppressor Cell HIV-1 Simian Immunodeficiency Virus Immunologic Memory Spleen Receptors NK Cell Lectin-Like |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 |
| Popis: | Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens. |
| Databáze: | OpenAIRE |
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