Angiostatic Activity of Steroids in the Chick Embryo CAM and Rabbit Cornea Models of Neovascularization
| Autor: | Abbot F. Clark, John M. Yanni, Lori K. Weimer, Loretta Mcnatt |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Hydrocortisone genetic structures Angiogenesis medicine.medical_treatment Anti-Inflammatory Agents Angiogenesis Inhibitors Chick Embryo In Vitro Techniques Pharmacology Biology Steroid Cornea Neovascularization Internal medicine medicine Animals Humans Pharmacology (medical) Glucocorticoids Dose-Response Relationship Drug Neovascularization Pathologic Choroid U937 Cells Choroidal Neovascularization eye diseases In vitro Disease Models Animal Ophthalmology Chorioallantoic membrane Endocrinology Mechanism of action Steroids Rabbits sense organs Anecortave acetate medicine.symptom Glucocorticoid Interleukin-1 medicine.drug |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 15:413-423 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.1999.15.413 |
| Popis: | Ocular neovascular diseases represent a major cause of blindness in the world. Angiostatic steroids are a unique class of compounds which inhibit the formation of new blood vessels in various models, including ocular models of angiogenesis. In search of potent new anti-angiogenic agents for the treatment of ocular neovascular disease, a large group of steroids were evaluated for angiostatic activity in the chick embryo CAM model. Angiostatic activity was found among all steroid classes included in the study. There was a good correlation between the angiostatic efficacies of 15 diverse steroids tested in the chick CAM and in the rabbit LPS-induced corneal pocket models of neovascularization (r=0.76, p=0.01). These studies show that potent angiostatic steroids inhibit neovascularization in two different animal models, suggesting a common mechanism of action. Glucocorticoid therapy is sometimes associated with ocular side effects. Two of the most potent angiostatic steroids, AL-3789 and AL-4940, were evaluated for glucocorticoid-mediated antiinflammatory activity in the in vitro U937 cell model of LPS-induced IL-1 induction and found to be devoid of glucocorticoid activity. Angiostatic steroids which lack glucocorticoid activity should be attractive drug candidates for treating ocular neovascular disease. |
| Databáze: | OpenAIRE |
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