Morinda citrifolia Linn Leaf Extract Possesses Antioxidant Activities and Reduces Nociceptive Behavior and Leukocyte Migration
| Autor: | Izabel Almeida Alves, Adriano Antunes de Souza Araújo, Lucindo José Quintans-Júnior, Leonardo Rigoldi Bonjardim, Paulo Cesar de Lima Nogueira, Adriana Gibara Guimarães, Mairim Russo Serafini, Daniel Pens Gelain, João Paulo Almeida dos Santos, Rodrigo Correia Santos, Alan D. C. Santos |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Leukocyte migration Antioxidant medicine.medical_treatment Anti-Inflammatory Agents Medicine (miscellaneous) Nitric Oxide Antioxidants Mice Cell Movement Leukocytes medicine Animals Morinda Chromatography High Pressure Liquid Analgesics Nutrition and Dietetics Phenol biology Traditional medicine Hydroxyl Radical Plant Extracts Chemistry Thiobarbiturates Nitric oxide metabolism biology.organism_classification Anti-Bacterial Agents Plant Leaves Lipid Peroxidation Medicine Traditional |
| Zdroj: | Journal of Medicinal Food. 14:1159-1166 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2010.0254 |
| Popis: | Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as "Noni") has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid-induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400 mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states. |
| Databáze: | OpenAIRE |
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