Costs of crowding for the transmission of malaria parasites

Autor: Sarah E. Reece, Emma J Dawes, Nick Colegrave, María-Gloria Basáñez, Thomas S. Churcher, Shahid M. Khan, Laura C. Pollitt, Mohammed Sajid
Přispěvatelé: Medical Research Council (MRC)
Jazyk: Afar
Rok vydání: 2013
Předmět:
Plasmodium berghei
LABORATORY MODELS
030231 tropical medicine
PLASMODIUM-FALCIPARUM INFECTION
SPOROGONIC CYCLE
vector-borne disease
03 medical and health sciences
0302 clinical medicine
0603 Evolutionary Biology
Genetics
medicine
Anopheles stephensi
programmed cell death
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
MOSQUITO RESISTANCE
disease transmission
0303 health sciences
Evolutionary Biology
IMMUNE DEFENSES
Science & Technology
biology
Transmission (medicine)
Ecology
BRIDGING SCALES
TRADE-OFFS
Original Articles
Infectious Disease Epidemiology
medicine.disease
biology.organism_classification
Crowding
ANOPHELES-GAMBIAE
3. Good health
fitness costs
density dependence
Vector (epidemiology)
life-history strategies
VECTORIAL CAPACITY
Evolutionary ecology
General Agricultural and Biological Sciences
Life Sciences & Biomedicine
Malaria
YOELII NIGERIENSIS INFECTION
Zdroj: Evolutionary Applications
Evolutionary Applications, 6(4), 617-629
Evolutionary Applications; Vol 6
Popis: The utility of using evolutionary and ecological frameworks to understand the dynamics of infectious diseases is gaining increasing recognition. However, integrating evolutionary ecology and infectious disease epidemiology is challenging because within-host dynamics can have counterintuitive consequences for between-host transmission, especially for vector-borne parasites. A major obstacle to linking within- and between-host processes is that the drivers of the relationships between the density, virulence, and fitness of parasites are poorly understood. By experimentally manipulating the intensity of rodent malaria (Plasmodium berghei) infections in Anopheles stephensi mosquitoes under different environmental conditions, we show that parasites experience substantial density-dependent fitness costs because crowding reduces both parasite proliferation and vector survival. We then use our data to predict how interactions between parasite density and vector environmental conditions shape within-vector processes and onward disease transmission. Our model predicts that density-dependent processes can have substantial and unexpected effects on the transmission potential of vector-borne disease, which should be considered in the development and evaluation of transmission-blocking interventions.
Databáze: OpenAIRE
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