Synthesis, characterization of inclusion compounds of amygdalin with β-cyclodextrin and sod-like activity and cytotoxicity on hela tumor cells
| Autor: | Narcis Duteanu, Roxana Liana Stan, Mariana Muresan, Eleonora Marian, Adriana Hangan, Gerlinde Rusu, Corina Ionescu, Bogdan Sevastre, Laura Vicas, Tunde Jurca, Emoke Pall, Otilia Micle |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
Cytotoxicity Amygdalin Inclusion compounds Free radicals 02 engineering and technology 010402 general chemistry 01 natural sciences HeLa lcsh:Chemistry Freeze-drying chemistry.chemical_compound In vivo chemistry.chemical_classification Cyclodextrin biology General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification In vitro 0104 chemical sciences chemistry lcsh:QD1-999 Cell culture β-cyclodextrin 0210 nano-technology Nuclear chemistry |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 8, Pp 6828-6837 (2020) |
| ISSN: | 1878-5352 |
| Popis: | In this work is presented the synthesis of the inclusion complexes of amygdalin with β-cyclodextrin by three methods: kneading, co-precipitation and freeze drying and their characterization. The inclusion compounds were synthesized using a molar ratio of amygdalin: β-cyclodextrin of 1:1. Synthesized compounds were analyzed by FTIR spectroscopy, X-rays, thermal analysis and the results confirm the formation of inclusion compounds by amygdalin with β-cyclodextrin. The studies carried out have shown the protective effect of amygdalin-β-cyclodextrin compounds obtained by freeze drying, kneading and coprecipitation against free radicals (SOD-like activity in vivo) and the results of in vitro cell cytotoxicity of the compounds on HeLa cell line compared to pure amygdalin. Compound obtained by freeze drying has the best SOD-like activity and cytotoxicity on HeLa tumor cells, so it may be considered as potential therapeutic agent. |
| Databáze: | OpenAIRE |
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