Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain

Autor: Bożena Leszczyńska-Gorzelak, Żaneta Kimber-Trojnar, Jan Oleszczuk, Dorota Darmochwal-Kolarz, Jolanta Patro-Małysza, Marcin Trojnar
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
obesity
excessive gestational weight gain
Physiology
Umbilical cord
Body Mass Index
Umbilical Cord
lcsh:Chemistry
0302 clinical medicine
Pregnancy
adipokines
lcsh:QH301-705.5
Spectroscopy
Leptin
General Medicine
Gestational Weight Gain
Computer Science Applications
medicine.anatomical_structure
ghrelin
Ghrelin
Female
medicine.symptom
Adult
Adipokine
030209 endocrinology & metabolism
Gestational Age
leptin
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Young Adult
Insulin resistance
medicine
Humans
Physical and Theoretical Chemistry
Eye Proteins
Molecular Biology
Adaptor Proteins
Signal Transducing

Glycated Hemoglobin
business.industry
Organic Chemistry
Membrane Proteins
medicine.disease
secreted frizzled-related protein 5
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
neonatal anthropometry
Linear Models
business
Weight gain
Body mass index
Zdroj: International Journal of Molecular Sciences, Vol 20, Iss 3, p 595 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 3
ISSN: 1422-0067
Popis: Among the new adipokines, secreted frizzled-related protein 5 (SFRP5) is considered to prevent obesity and insulin resistance. The umbilical cord SFRP5 levels have not yet been investigated. The main aim of the study was to investigate whether the umbilical cord SFRP5 concentrations are altered in term neonates born to mothers with excessive gestational weight gain (EGWG). Two groups of subjects were selected depending on their gestational weight gain, i.e. 28 controls and 38 patients with EGWG. Umbilical cord and maternal serum SFRP5 levels were lower in the EGWG group. Umbilical cord SFRP5 concentrations were directly associated with the maternal serum SFRP5, hemoglobin A1c and lean tissue index, umbilical cord leptin levels, as well as newborns&rsquo
anthropometric measurements in the EGWG subjects. In multiple linear regression models performed in all the study participants, umbilical cord SFRP5 concentrations depended positively on the maternal serum SFRP5, ghrelin, and leptin levels and negatively on the umbilical cord ghrelin levels, low-density lipoprotein cholesterol, pre-pregnancy body mass index, and gestational weight gain. EGWG is associated with disturbances in SFRP5 concentrations. Obstetricians and midwives should pay attention to nutrition and weight management during pregnancy.
Databáze: OpenAIRE
Nepřihlášeným uživatelům se plný text nezobrazuje