Purine Nucleotide Catabolism in Rat Liver

Autor:	Giuliano Cinci, Lucia Terzuoli, Roberto Pagani, Enrico Marinello, L. Arezzini, Brunetta Porcelli
Rok vydání:	2006
Předmět:	Male chemistry.chemical_classification Allopurinol Nucleotide Metabolism Rats Uric Acid De novo synthesis chemistry.chemical_compound Allantoin Liver chemistry Biochemistry Labelling medicine Animals Uric acid Nucleotide Rats Wistar Xanthine oxidase Purine Nucleotides medicine.drug
Zdroj:	Purine and Pyrimidine Metabolism in Man X ISBN: 0306465159 ResearcherID Università degli Studi di Siena-IRIS Scopus-Elsevier
Popis:	The higher specific radioactivity of ALL in comparison to UA, which are observed after administration of labelled precursors, changed when, oxonic acid and allopurinol, inhibitors of UA and ALL formation were administrated. To interpret these results, it is worth while to recall that nucleotide metabolism can be represented as a complex sequence including de novo synthesis of nucleotides and their degradation to UA and ALL. UA is both partially exported to the blood and partially transformed into ALL, which is totally exported to the blood. Under normal conditions, the radioactivity of UA and ALL is similar, in the case of14 C-glycine, while in the other cases (after 14C-formate and other precursors), the formation of ALL is so fast, that it exceedes export from liver to serum, and the radioactivity of the precursors accumulates in ALL. When we treated with the oxonic acid and allopurinol, formation of ALL was reduced, became slower than its export, leading to a higher labelling into UA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45673eabbf3acbe6b49b6452ceaabee https://doi.org/10.1007/0-306-46843-3_20 Zobrazit plný text záznamu