The association of BDNF gene polymorphism with cognitive impairment in insomnia patients
| Autor: | John F. W. Zaki, Seithikurippu R. Pandi-Perumal, Ahmed S. BaHammam, Nevin F W Zaki, Elhasanein Mahmoud, Mahmoud Elwasify, David Warren Spence, El-Sayed Saleh |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Polysomnography Neuropsychological Tests Polymorphism Single Nucleotide 03 medical and health sciences Young Adult 0302 clinical medicine Rating scale Polymorphism (computer science) Internal medicine Sleep Initiation and Maintenance Disorders Surveys and Questionnaires mental disorders medicine Insomnia Humans Genetic Predisposition to Disease Biological Psychiatry Depression (differential diagnoses) Alleles Pharmacology medicine.diagnostic_test business.industry Brain-Derived Neurotrophic Factor Montreal Cognitive Assessment Middle Aged 030227 psychiatry Female Gene polymorphism medicine.symptom business Cognition Disorders rs6265 |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 88 |
| ISSN: | 1878-4216 |
| Popis: | Background Reductions in BDNF activity have shown associations with depressed mood. Other evidence has demonstrated that the BDNF Val66Met polymorphism (rs6265) appears to reduce neural plasticity. A limited number of studies have investigated the influence of these genetic polymorphisms in insomnia. The present study sought to confirm the presence of associations between BDNF Val66Met polymorphism (rs6265) occurrence in normal sleepers and those with insomnia. Method The study subjects consisted of a patient group (n = 199) complaining of insomnia and a control group (n = 51). Each subject was clinically interviewed using questions taken from the Brief Insomnia Questionnaire. After the interview, the subjects were asked to complete the Insomnia Severity Index, The Hamilton Depression Rating Scale, and the Montreal Cognitive Assessment Test. An overnight polysomnography test was also administered. Blood samples were collected for genetic study. Results The insomnia patients showed a greater prevalence of heterozygous (A/G) VAL/MET polymorphism than the normal controls (p = ≤ 0.0001). This finding confirmed that this genetic polymorphism, which impairs BDNF activity, is an important correlate of disturbed sleep. Further, the finding of significantly greater (p = ≤ 0.0001) depression scores among the insomnia group suggested that BDNF is an important factor in the development of depressive symptoms. Clinical Implications The results of the present study indicate that BDNF gene polymorphism plays a prominent role in the variation of symptoms among insomnia patients and, further, that this polymorphism is strongly related to the severity of depression. |
| Databáze: | OpenAIRE |
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