Regulatory processes that control haploid expression of salmon sperm mRNAs
| Autor: | Jong S. Leong, Ben F. Koop, Kristian R. von Schalburg, William S. Davidson, Eric Rondeau |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male endocrine system Spermiogenesis Recognition elements lcsh:Medicine Posttranscriptional processing Biology Haploidy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Recognition sequence Salmon Gene expression medicine Animals RNA Messenger lcsh:Science (General) lcsh:QH301-705.5 Gene 3' Untranslated Regions urogenital system Messenger RNA lcsh:R Translation (biology) General Medicine Sperm Spermatozoa Cell biology Open reading frame Research Note 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Gamete 5' Untranslated Regions 5′-untranslated regions Function (biology) lcsh:Q1-390 Localization motifs |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018) |
| ISSN: | 1756-0500 |
| Popis: | Objective Various stages of mRNA processing are necessary for functionally important genes required during late-stage sperm differentiation. Protein–RNA complexes form that edit, stabilize, store, deliver, localize and regulate translation of sperm mRNAs. These regulatory processes are often directed by recognition sequence elements and the particular composition of the proteins associated with the mRNAs. Previous work has shown that the cAMP response element modulator (CREM), estrogen receptor-alpha (ERα) and forkhead box L2A (FOXL2A) proteins are present in late-stage salmon sperm. Here we investigate whether these and other regulatory proteins might control processing of mRNAs not expressed until the haploid stage of development. We also examine regulatory processes that prepare and present mRNAs that generate unique products essential for differentiating sperm (i.e. for flagellar assembly and function). Results We provide evidence for potential sperm-specific recognition elements in 5′-untranslated regions (utrs) that may bind CREM, ERα, FOXL2A, Y-box and other proteins. We show that changes within the 5′-utrs and open reading frames of some sperm genes lead to distinct protein termini that may provide specific interfaces necessary for localization and function within the paternal gamete. Electronic supplementary material The online version of this article (10.1186/s13104-018-3749-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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