Association of IgA deficiency with HLA A28 and B14
| Autor: | F.T. Christiansen, T J Cobain, R. L. Dawkins, M.A.H. French |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Immunology clinic
biology business.industry Immunology General Medicine Human leukocyte antigen Serum iga Major histocompatibility complex Biochemistry Immunoglobulin A Blood donor HLA Antigens Genetics biology.protein Immunology and Allergy Medicine Humans IgA deficiency Dysgammaglobulinemia business |
| Zdroj: | Tissue antigens. 22(2) |
| ISSN: | 0001-2815 |
| Popis: | HLA typing was performed in two groups of individuals with low serum IgA concentrations. These consisted of 44 individuals identified from a blood donor clinic and 37 individuals attending an Immunology clinic with disorders associated with IgA deficiency. Both groups showed an increase in the frequency of HLA B14 (p less than 0.0001), HLA-A28 (P = 0.0007) and the combinations HLA-A1, B14 and HLA-A28, B14. The previously reported increase in HLA-A1, B8 was not apparent in either group. These data suggest that there is a gene within the human major histocompatibility complex which is relevant in IgA deficiency. |
| Databáze: | OpenAIRE |
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