Dissociation of serum LATS content and thyroid suppressibility during treatment of hyperthyroidism
| Autor: | Delores E. Johnson, David H. Solomon, Inder J. Chopra, Usha Chopra, Delbert A. Fisher |
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| Rok vydání: | 1970 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases Antithyroid drugs Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyroid Gland Thyrotropin Thyroid Function Tests Biochemistry Hyperthyroidism Immunoglobulin G Iodine Radioisotopes Endocrinology Internal medicine medicine Humans Euthyroid Aged Triiodothyronine Methimazole biology business.industry Goiter Biochemistry (medical) Thyroid Middle Aged medicine.anatomical_structure Propylthiouracil biology.protein Long-Acting Thyroid Stimulator business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 30(4) |
| ISSN: | 0021-972X |
| Popis: | Serum LATS content and suppressibility of 20-min thyroid 131I uptake have been examined at frequent intervals in 15 patients with hyperthyroidism due to Graves' disease during treatment with antithyroid drugs. LATS was measured in precisely 10-fold concentrates of immunoglobulin G prepared by salt fractionation. The method had an average recovery of 95% and was sensitive to 0.13 MRC mU/ml. After 4.5 to 7.5 months of treatment, thyroid 131I uptake became suppressible by triiodothyronine in 4 patients; in only 2 of these was LATS undetectable. Among 11 patients in whom 131I uptake was not suppressible after 4.5 to 12 months of treatment, LATS was undetectable in 7. Serum TSH was also measured, and its reappearance in normal or supranormal concentrations, as the patients became euthyroid or hypothyroid, was not associated with normalization of suppression of 131I uptake by triiodothyronine. These data lend no support to the hypothesis that nonsuppressibility in Graves' disease is due to circulating ... |
| Databáze: | OpenAIRE |
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