A thin hydrogel barrier linked onto cell surface sialic acids through covalent bonds induces cancer cell death in vivo
| Autor: | Yuka Sanada, Koji Nagahama, Yuka Kimura, Kimika Ono, Seika Aoyama, Tokitaka Katayama, Natsumi Ueda |
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| Rok vydání: | 2019 |
| Předmět: |
Glycan
Cell Biomedical Engineering Antineoplastic Agents 010402 general chemistry 01 natural sciences 03 medical and health sciences chemistry.chemical_compound In vivo medicine Carbohydrate Conformation Cell Adhesion Humans General Materials Science Receptor 030304 developmental biology Cell Proliferation 0303 health sciences biology Cell Death Chemistry Cell Membrane Cancer Hydrogels medicine.disease N-Acetylneuraminic Acid 0104 chemical sciences Cell biology Sialic acid medicine.anatomical_structure Self-healing hydrogels Cancer cell biology.protein MCF-7 Cells Drug Screening Assays Antitumor |
| Zdroj: | Biomaterials science. 8(2) |
| ISSN: | 2047-4849 |
| Popis: | Hypersialylation is the aberrant expression of sialic acid in cell surface glycans and is pervasive in cancer cells. Recent studies have shown that hypersialylation provides a microenvironment conducive to cancer progression, mediated by the interaction between sialic acid and sialic acid-binding receptors. Therefore, a technique to block the interaction between the overexpressed sialic acid on cancer cell surfaces and its receptors is a promising approach to develop new cancer therapies. We focused on hydrogels as an artificial barrier to block this interaction and present here the development of a novel technique for selectively covalently binding a thin hydrogel barrier on sialic acid residues on cancer cell surfaces. This technique effectively inhibited cancer cell adhesion, motility and growth, caused cancer cell death in vitro, and completely suppressed tumor growth in vivo, thereby clearly demonstrating a potent antitumor effect. |
| Databáze: | OpenAIRE |
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