Levonorgestrel correlates with less weight gain than other progestins during hormonal replacement therapy in Turner Syndrome patients
Autor: | Ieda Therezinha do Nascimento Verreschi, Magnus R. Dias-da-Silva, Patrícia Teófilo Monteagudo, Andréia Latanza Gomes Mathez |
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Rok vydání: | 2019 |
Předmět: |
Endocrine reproductive disorders
Adult endocrine system Medroxyprogesterone Adolescent medicine.drug_class medicine.medical_treatment Population lcsh:Medicine Physiology Turner Syndrome 030209 endocrinology & metabolism Levonorgestrel Weight Gain Article Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine Turner syndrome medicine Humans lcsh:Science education Author Correction Retrospective Studies education.field_of_study 030219 obstetrics & reproductive medicine Multidisciplinary business.industry lcsh:R Estrogen Replacement Therapy Hormone replacement therapy (menopause) medicine.disease Cross-Sectional Studies Treatment Outcome Contraceptive Agents Hormonal lcsh:Q Female medicine.symptom Progestins business Hormonal therapies Weight gain Progestin Dyslipidemia medicine.drug |
Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
ISSN: | 2045-2322 |
Popis: | Turner Syndrome (TS) is associated with an increased risk of cardiovascular and metabolic complications. Furthermore, TS women need hormone replacement therapy (HRT), of which progestins can influence body weight. We aimed to analyze the metabolic and weight profile in a cohort of 111 TS women. They started receiving estrogen at 15.8 (±3.6) years old, with no change in hypertension, dysglycemia, and dyslipidemia incidence but with a tendency to increase overweight (p = 0.054). As the first used type of progestin, most had received cycles of 10 days per month of medroxyprogesterone (MPA) or levonorgestrel (LNG), then shifted to micronized progesterone (MP), which has currently become the most used one. By multiple linear regression analysis, we found that the prolonged use of MPA, LNG, or MP showed no metabolic change except for weight gain. The percentage of annual BMI increment was positive for all progestins used in TS women (MPA 2.2 ± 2.2; LNG 0.2 ± 1.2; and MP 2.2 ± 2.6 kg/m2), but LNG seemed to best prevent on weight gain over time (p 0.05). In conclusion, metabolic comorbidities are prevalent in TS even before the HRT regimen, and LNG performed better on less weight gain than MPA and MP in our cohort of the TS population. |
Databáze: | OpenAIRE |
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