Phylogenetic analysis of a swine influenza A(H3N2) virus isolated in Korea in 2012
| Autor: | Jun Heo, Sehee Park, Man Seong Park, Kabsu Kim, Donghwan Kim, Jin Il Kim, Min Woong Hwang, Joon Yong Bae, Seok Il Jang, Ilseob Lee, Sangmoo Lee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Swine
Epidemiology viruses Reassortment lcsh:Medicine Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus medicine.disease_cause Microbiology Virus Viral Evolution Infectious Disease Epidemiology Veterinary Epidemiology Orthomyxoviridae Infections Virology Zoonoses Reassortant Viruses Influenza Human Republic of Korea Influenza A virus medicine Animals Cluster Analysis Humans Evolutionary Systematics lcsh:Science Biology Phylogeny Avian influenza A viruses Swine Diseases Evolutionary Biology Multidisciplinary Viral matrix protein biology Influenza A Virus H3N2 Subtype lcsh:R Phylogenetics Emerging Infectious Diseases Viral evolution biology.protein Medicine Infectious diseases lcsh:Q Veterinary Science Neuraminidase Algorithms Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 2, p e88782 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Influenza A virus (IAV) can infect avian and mammalian species, including humans. The genome nature of IAVs may contribute to viral adaptation in different animal hosts, resulting in gene reassortment and the reproduction of variants with optimal fitness. As seen again in the 2009 swine-origin influenza A H1N1 pandemic, pigs are known to be susceptible to swine, avian, and human IAVs and can serve as a 'mixing vessel' for the generation of novel IAV variants. To this end, the emergence of swine influenza viruses must be kept under close surveillance. Herein, we report the isolation and phylogenetic study of a swine IAV, A/swine/Korea/PL01/2012 (swPL01, H3N2 subtype). After screening nasopharyngeal samples from pigs in the Gyeongsangnam-do region of Korea from December 2011 to May 2012, we isolated the swPL01 virus and sequenced its all of 8 genome segments (polymerase basic 2, PB2; polymerase basic 1, PB1; polymerase acidic, PA; hemagglutinin, HA; nucleocapsid protein, NP; neuraminidase, NA; matrix protein, M; and nonstructural protein, NS). The phylogenetic study, analyzed with reference strains registered in the National Center for Biotechnology Information (NCBI) database, indicated that the swPL01 virus was similar to the North American triple-reassortant swine strains and that the HA gene of the swPL01 virus was categorized into swine H3 cluster IV. The swPL01 virus had the M gene of the triple-reassortant swine H3N2 viruses, whereas that of other contemporary strains in Korea was transferred from the 2009 pandemic H1N1 virus. These data suggest the possibility that various swine H3N2 viruses may co-circulate in Korea, which underlines the importance of a sustained surveillance system against swine IAVs. |
| Databáze: | OpenAIRE |
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