Pleiotropic mutations can rapidly evolve to directly benefit self and cooperative partner despite unfavorable conditions
| Autor: | Chi-Chun Chen, Samuel F. M. Hart, Wenying Shou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
genetic structures QH301-705.5 Science S. cerevisiae Saccharomyces cerevisiae Biology complex mixtures General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pleiotropy Cooperative community pleiotropy Biology (General) cross-feeding Hypoxanthine Genetics Evolutionary Biology General Immunology and Microbiology Ecology win-win mutations General Neuroscience Genetic Pleiotropy General Medicine Limiting Biological Evolution 030104 developmental biology chemistry Mutation Medicine bacteria Research Advance evolution of cooperation 030217 neurology & neurosurgery partner-serving cooperative community |
| Zdroj: | eLife eLife, Vol 10 (2021) |
| ISSN: | 2050-084X |
| Popis: | Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic ‘win-win’ mutations which directly benefit self (self-serving) and partner (partner-serving). Previously, we showed that partner-serving should be defined as increased benefit supply rate per intake benefit. Here, we report that win-win mutations can rapidly evolve even under conditions unfavorable for cooperation. Specifically, in a well-mixed environment we evolved engineered yeast cooperative communities where two strains exchanged costly metabolites, lysine and hypoxanthine. Among cells that consumed lysine and released hypoxanthine, ecm21 mutations repeatedly arose. ecm21 is self-serving, improving self’s growth rate in limiting lysine. ecm21 is also partner-serving, increasing hypoxanthine release rate per lysine consumption and the steady state growth rate of partner and of community. ecm21 also arose in monocultures evolving in lysine-limited chemostats. Thus, even without any history of cooperation or pressure to maintain cooperation, pleiotropic win-win mutations may readily evolve to promote cooperation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|