Sympathetic Neural and Hemodynamic Responses During Cold Pressor Test in Elderly Blacks and Whites
| Autor: | Stuart A. Best, Qi Fu, Beverley Adams-Huet, Yoshiyuki Okada, Joseph M. Hendrix, Benjamin D. Levine, Sara S. Jarvis, Jeffrey G. Edwards, Wanpen Vongpatanasin |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Aging medicine.medical_specialty Cardiac output Sympathetic Nervous System Supine position Diastole Black People Hemodynamics 030204 cardiovascular system & hematology Statistics Nonparametric White People Cohort Studies Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate Internal Medicine medicine Humans Prospective Studies Cardiac Output Aged Aged 80 and over Analysis of Variance Chi-Square Distribution Diagnostic Tests Routine business.industry Cold pressor test Blood Pressure Determination Middle Aged Cold Temperature Blood pressure Vasoconstriction Anesthesia Hypertension Cardiology Female Vascular Resistance medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Hypertension. 67:951-958 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hypertensionaha.115.06700 |
| Popis: | The sympathetic response during the cold pressor test (CPT) has been reported to be greater in young blacks than whites, especially in those with a family history of hypertension. Because blood pressure (BP) increases with age, we evaluated whether elderly blacks have greater sympathetic activation during CPT than age-matched whites. BP, heart rate, cardiac output, and muscle sympathetic nerve activity were measured during supine baseline, 2-minute CPT, and 3-minute recovery in 47 elderly (68±7 [SD] years) volunteers (12 blacks and 35 whites). Baseline BP, heart rate, cardiac output, or muscle sympathetic nerve activity did not differ between races. Systolic and diastolic BP and heart rate increased during CPT (all P P >0.05). Cardiac output increased during CPT and ≤30 s of recovery in both groups, but was lower in blacks than whites. Muscle sympathetic nerve activity increased during CPT in both groups (both P P =0.030 for interaction). Peak change (Δ) in diastolic BP was correlated with Δ total activity at 1 minute into CPT in both blacks ( r =0.78, P =0.003) and whites ( r =0.43, P =0.009), whereas the slope was significantly greater in blacks ( P =0.007). Thus, elderly blacks have smaller sympathetic and central hemodynamic (eg, cardiac output) responses, but a greater pressor response for a given sympathetic activation during CPT than elderly whites. This response may stem from augmented sympathetic vascular transduction, greater sympathetic activation to other vascular bed(s), or enhanced nonadrenergically mediated vasoconstriction in elderly blacks. |
| Databáze: | OpenAIRE |
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